IL-10 synergizes with multiple cytokines in enhancing HIV production in cells of monocytic lineage
Article Abstract:
Low concentrations of interleukin (IL)-10 increase HIV replication in mononuclear phagocytes. Previous experiments have shown high concentrations of IL-10 to inhibit HIV replication in monocyte-derived macrophages (MDM). Researchers analyzed the effects of low IL-10 concentrations and other cytokines on HIV infected MDM and on the promonocytic U1 cell line. IL-10 alone did not stimulate HIV production. However, IL-10 along with other cytokines, particularly IL-1, IL-4, and tumor necrosis factor-alpha, stimulated HIV production. IL-10 in conjunction with these other cytokines did not increase the proliferation of HIV infected cells, but did increase the replication of HIV within cells. This enhanced replication did not depend on stimulation of the NF-kappa-B or Sp1 regions of the viral DNA.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Viral load and immunophenotype of cells obtained from lymph nodes by fine needle aspiration as compared with peripheral blood cells in HIV-infected patients
Article Abstract:
Fine needle aspiration can be a noninvasive method of sampling immune cells and of assessing the amount of virus in palpable lymph nodes of HIV patients. A comparison between samples of biopsied lymph node cells (LNC) and peripheral blood mononuclear cells (PBMC) taken from 17 HIV-infected patients showed a difference in HIV RNA content and viral load. Both the viral load and RNA counts were higher in lymphoid tissue than in the blood cell samples.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Interleukin-10 enhances tumor necrosis factor-alpha activation of HIV-1 transcription in latently infected T cells
Article Abstract:
Interleukin-10 (IL-10) appears to stimulate HIV reproduction by activating tumor necrosis factor-alpha (TNF-alpha). Researchers studied the effect of IL-10 in a T cell culture that was infected with HIV-1. IL-10 inhibited viral reproduction but when TNF-alpha was added, HIV reproduction increased. IL-10 appeared to stimulate the production of TNF-alpha, which occurs naturally in the human body.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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