Axonal sprouting in hippocampus of cats infected with feline immunodeficiency virus (FIV)

Article Abstract:

Neurologic changes associated with HIV infection may be related to structural alterations in the hippocampus of the brain. HIV infection may cause seizures and changes in memory and behavior. Researchers examined the hippocampus of healthy cats and cats infected with feline immunodeficiency virus (FIV), a disease similar to HIV. Cats with FIV had excess glial cells in the dentate gyrus and nerve axon sprouting. FIV infection caused changes in granule cell axons in the hippocampus, a region of the brain associated with behavior. Similar changes may accompany HIV infection in humans.

Abnormalities, Physiological aspects, Hippocampus (Brain)

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Effects of feline immunodeficiency virus on cognition and behavioral function in cats

Article Abstract:

A study on cats shows that early HIV infection can cause behavioral and intellectual defects. Researchers gave a battery of behavioral and intellectual tests to six cats who had been infected with feline immunodeficiency virus (FIV) 12 months before the experiment and six healthy non-infected cats. The FIV-infected cats showed significant defects in memory, learning and behavior. They were also less able to cross narrow planks, indicating possible defects in muscle activity.

Health aspects, Behavior, Cats as laboratory animals, Domestic cats, Laboratory animals

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