IL-23: A master regulator in Crohn disease

Article Abstract:

The pro-inflammatory cytokine interleukin (IL)-23 is used as a therapeutic target in inflammatory bowel disease and other autoimmune and chronic inflammatory diseases. A controlled trial of patients with Crohn disease has shown that an antibody to the p40 subunit of IL-12/IL-23 has resulted in higher rates of clinical responses and remissions compared to placebo therapy, indicating that targeting both IL-12 and IL-23 reduces pro-inflammatory cytokine production by mucosal immune cells.

Germany, Care and treatment, Inflammatory bowel diseases, Crohn's disease

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Effector CD8(super +) T cells mediate inflammation and airway hyper-responsiveness

Article Abstract:

The CD8-deficient mice develop significantly lower airway hyper-responsiveness (AHR), eosinophilic inflammation and interleukin (IL)-13 levels in bronchoalveolar lavage fluid compared with wild-type mice. A study conducted with CD8(super +) T cells for the same purpose reveals that these responses are restored from IL-13-sufficient, but not IL-13-deficient mice.

Pulmonary eosinophilia

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Negative regulation of airway responsiveness that is dependent on gamma/delta T cells and independent of alpha/beta T cells

Article Abstract:

Gamma/delta T cells can regulate airway responsiveness and this effect is independent of alpha/beta T cells. Gamma/delta T cells are constitutively expressed in pulmonary tissue.

Physiological aspects, Airway (Medicine), Airway

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