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Lymphangiogenesis in development and human disease

Article Abstract:

Lymphangiogenesis research has provided imminent therapeutic applications for human diseases such as lymphoedema and other tissue oedemas that will enter clinical development in the near future. The importance of lymph-node metastasis in the spread of cancer to distant organs needs to be better understood before the new knowledge can be applied to patients and recent developments in lymphatic vascular biology will lead to a better understanding and treatment of human diseases.

Author: Alitalo, Kari, Petrova, Tatiana, Tammela, Tuomas
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
United States, Research and Development in the Physical, Engineering, and Life Sciences, Forecasts, trends, outlooks, Research and Testing Services, Cancer & Cell R&D, Forecasts and trends, Cancer research, Market trend/market analysis, Cancer, Edema, Oncology, Experimental, Lymphatic metastasis, Dropsy

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Gene transfer as a tool to induce therapeutic vascular growth

Article Abstract:

A treatment option may be provided by therapeutic induction of vascular growth for patients with myocardial or peripheral ischemia who are not suited to conventional revascularization therapies. Gene therapy could lead to correction of the genetic causes of disease but problems still exist when considering the development of safe long-term treatments for monogenic disorders.

Author: Yla-Herttuala, Seppo, Alitalo, Kari
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Heart diseases, Gene therapy, Cardiomyopathy, Myocardial diseases, Genetic transformation

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Therapeutic differentiation and maturation of lymphatic vessels after node dissection and transplantation

Article Abstract:

A study showing that collecting lymphatic vessels can be regenerated and fused to lymph node transplants after removing lymph node is conducted. Results show that growth factor-induced maturation of lymphatic vessels is possible in adult mice providing a basis for future therapy of lymphedema.

Author: Yla-Herttuala, Seppo, Alitalo, Kari, Tammela, Tuomas, Petrova, Tatiana V., Saaristo, Anne, Holopainen, Tanja, Lyytikka, Johannes, Kotronen, Anna, Pitkonen, Miia, Abo-Ramadan, Usama
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
Lymphedema, Lymph nodes, Lymphatic vessels

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Subjects list: Care and treatment, Research
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