Immune therapeutics in the HAART era; how should they be tested in clinical trials

Article Abstract:

Therapeutic HIV vaccines are designed to modulate host factors, which could control HIV replication and immune deficiency. A number of studies conducted are reviewed and the results are limited because of combination of factors such as lack of vaccine potency, the discordance between immune effect and virologic outcome and the ambiguous role of adjuvants, cytokine enhancement and innate immunity.

United States, Care and treatment, HIV infection, HIV infections, Highly active antiretroviral therapy

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A CCR5-tropic simian-HIV molecular clone capable of inducing AIDS in rhesus macaques

Article Abstract:

A simian-HIV (SHIV) molecular clone expressing the entire env gp160 of SHIV(sub SF162 P3), termed SHIV P3gp160 can fully recapitulate the in vivo replicative characteristics of the parental isolate. Its use should be of practical value not only in studies of viral pathogenesis and transmission but for the optimization of challenge viruses in vaccine trials.

Genetic aspects, Cloning, Rhesus monkey

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Pathogenic determinants of the mucosally transmissible CXCR4-specific SHIV(sub SF33A2) map to env region

Article Abstract:

Researchers created a version of simian-human immunodeficiency viruses that contain an envelope sequence from HIV-1(sub SF33). Rhesus monkeys that were infected with this virus developed the monkey version of AIDS within nine months.

Simian immunodeficiency virus

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