Impact of missing data due to dropouts on estimates of the treatment effect in a randomized trial of antiretroviral therapy for HIV-infected individuals

Article Abstract:

A high rate of dropouts in trials of AIDS drugs could lead to an underestimation or overestimation of the drugs' effects. Researchers analyzed CD4 cell counts in 245 HIV-infected people enrolled in a trial comparing zidovudine (AZT) and didanosine (ddI). Only half the participants completed the 48-week study. Participants with lower CD4 counts were more likely to drop out. More people taking zidovudine dropped out due to side effects. Various methods were used to estimate the CD4 counts of the people who dropped out assuming they had remained in the study. At various times throughout the study, the CD4 counts of those who dropped out were estimated to be lower than the counts of those who remained in the study. The average change in CD4 count was also greater in those who dropped out. This indicates that the treatment would be assumed to have a greater effect than it actually did.

Analysis, Drugs, Testing, Dropouts

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Relationship between antiretroviral prescribing patterns and treatment guidelines in treatment-naive HIV-1-infected US veterans (1992-2004)

Article Abstract:

Retrospective cohort study is used to evaluate the temporal patterns of antiretroviral (ARV) prescribing practices that are relative to nationally defined guidelines in treatment-naive patients with HIV-1 infection. The results have shown that the U.S. department of Veterans Affairs (VA) prescribing patterns for ARV initiation has followed the treatment guidelines that maximize safety.

Patient outcomes, Antiviral agents, Antiretroviral agents, Clinical report

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Predicting HIV RNA virologic outcome at 52-weeks follow-up in antiretroviral clinical trials

Article Abstract:

HIV patients who do not initially respond to triple combination therapy may eventually respond. On the other hand, patients on double combination therapy who do respond initially may relapse and those who do not respond may never respond.

Viremia

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