Impaired prostate tumorigenesis in EGr1-deficient mice

Article Abstract:

Research presented concerns the relationship between the overexpression of early growth response protein 1 (EGR1) and human prostate cancer. The impact of Egr1 deficiency on tumorigenesis is discussed, as well as Egr1's role in regulating the development from prostatic intra-epithelial neoplasia to invasive carcinoma.

Prostate cancer, Genetic regulation, Genetic transcription, Transcription (Genetics)

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Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia

Article Abstract:

The functions of Nor-1 and Nur77 as critical tumor suppressors of myeloid leukemogenesis which might provide potential targets for therapeutic intervention of acute myeloid leukemia (AML) are described.

Science & research, Care and treatment, Genetic aspects, Tumor suppressor genes, Acute myelocytic leukemia, Tumour suppressor genes

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Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

Article Abstract:

Nicotine clearly induces angiogenesis, accelerates tumor growth, and promotes atherosclerosis. These effects are mediated by nocotinic acetylcholine receptors at significantly high concentrations.

Health aspects, Causes of, Nicotine, Neovascularization, Atherosclerosis

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