Important role of 72-kd heat shock protein expression in the endothelial cell in acquisition of hypoxic-ischemic tolerance in the immature rat

Article Abstract:

Heat shock protein 72 appears to protect the brain from low blood levels of oxygen, according to a study in rats. This protein is produced when the body is exposed to high temperatures.

Fever, Hyperthermia

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Hypoxic-ischemic tolerance phenomenon observed in neonatal rat brain

Article Abstract:

Preconditioning with four hours of hypoxic exposure significantly reduced hypoxic-ischemic brain damage in neonatal rats. An elevation in heat shock cognate protein messenger ribonucleic acid may account for the increased hypoxic-ischemic tolerance in the brain. Brain damage involved either generalized infarction or neuronal loss in the hippocampus.

Cerebral ischemia, Cerebral anoxia

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Heat shock protein 72 expression and microtubule-associated protein 2 disappearance after hypoxia-ischemia in the developing rat brain

Article Abstract:

Very young rats appear to produce heat shock protein (HSP) 72 sooner after a stressful event than older rats and this may protect their brains from injury. HSP72 is a protein that is released after some shock to the body, such as excessive heat, low oxygen levels or an interruption in the blood supply. It is believed to protect the body from being damaged by these stressful conditions. In a study of rats, 5-day-old rats produced HSP72 sooner than 14-day-old rats after the rats were exposed to low oxygen levels. Their brains also showed less damage from the stress.

Measurement, Prevention

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