In utero hematopoietic stem cell transplantation: a status report

Article Abstract:

In utero hematopoietic stem cell transplantation has only been successful in a few fetuses so far but the technique still has promise. It involves transplanting stem cells, which are the precursor of all blood cells, into a fetus while it is still in the womb. So far, it has only been effective in fetuses with immunodeficiency diseases such as severe combined immunodeficiency disease (SCID). In the past, stem cells from aborted fetuses were used, but umbilical cord blood from newborn babies may be a better source in the future. The mother must decide whether to accept the treatment and thus extensive counseling is recommended.

Hematopoietic stem cells, Hematopoietic stem cell transplantation, Fetal diseases

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Bone marrow transplantation in severe combined immunodeficiency from a sibling who had received a paternal bone marrow transplant

Article Abstract:

Receiving bone marrow transplants from her sister restored the immune system of a one-month-old infant girl with severe combined immunodeficiency. Having had the same condition, the six-year-old donor had originally received bone marrow cells from her father at the age of eight months and 31 months. The immune status of the newborn improved within one month after transplantation. T cells in her system were of paternal origin and she continued to develop normally for her age. There were no complications related to graft rejection or incompatibility.

Physiological aspects, Brothers and sisters

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Treatment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow

Article Abstract:

Transplanting enriched paternal bone marrow into the fetus while in the womb can prevent the lethal outcome of X-linked severe combined immunodeficiency, a multiple genetic defect. After diagnosing prenatal severe combined immunodeficiency in a fetus, researchers injected bone marrow obtained from the father of the infant and enriched with CD34+ cells in three doses into the fetus in the middle of the pregnancy. The now 11-month-old child has been healthy since birth with a normal history of upper respiratory tract and ear infections.

Fetus, Surgery, Fetal surgery

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