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In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

Article Abstract:

Research indicates that caveolin-1 scaffolding domain is able to selectively regulate endothelial nitric oxide synthase (eNOS) signal transduction, resulting in the suppression of vascular leak and acute inflammation similar to a glucocorticoid. Implications for therapeutic approaches via small-molecule mimicry are discussed.

Author: Sessa, William C., Bucci, Mariarosaria, Gratton, Jean-Philippe, Rudic, Radu Daniel, Acevedo, Lisette, Roviezzo, Fiorentina, Cirino, Giuseppe
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Italy, Caveolins

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Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway

Article Abstract:

Research presented concerns the regulation of penile erection, focusing on the impact of Rho-kinase antagonism on cavernosal tissue, smooth muscle cells, and blood pressure in rats. Findings suggest that Rho-kinase antagonism initiates an erectile response independently of nitric oxide.

Author: Chitaley, Kanchan, Wingard, Christopher J., Webb, R. Clinton, Branam, Heather, Stopper, Vivienne S., Lewis, Ronald W., Mills, Thomas M.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Research, Smooth muscle, Sex (Biology), Penis

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Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids

Article Abstract:

Researchers have discovered a peptide produced by monocytes in the presence of glucocorticoids that has anti-inflammatory properties. Thymosin beta4 sulfoxide inhibited neutrophil chemotaxis and limited edema in a study in mice.

Author: Lawrence, A.J., Stevenson, R.D., McInnes, I.B., Young, J.D., MacLean, A.G., Leung, B.P., Canas, B., Pappin, D.J.C.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Monocytes

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Subjects list: Statistical Data Included, United States, Physiological aspects, Corticosteroids, Adrenocortical hormones, Inflammation, Inflammation mediators, Nitric oxide
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