In vivo imaging of islet transplantation

Article Abstract:

The in vivo detection of transplanted human pancreatic islets are reported using magnetic resonance imaging (MRI) that allowed noninvasive monitoring of islet grafts in diabetic mice in real time. The result shows the feasibility of longitudinal noninvasive monitoring of transplanted human islets in diabetic mice using MRI.

Massachusetts, Patient outcomes, Type 1 diabetes, Magnetic resonance imaging, Pancreas transplantation

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Heart transplantation in baboons using alpha-1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience

Article Abstract:

Hearts from alpha-1,3-galactosyltransferase knockout pigs were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen. The elimination of the galactose-alpha-1,3-galactose epitope prevented hyperacute rejection and extended the survival of pig hearts in baboons for 2-6 months.

United States, Science & research, Hogs, Hog and Pig Farming, Research, Genetic aspects, Swine, Heart, Animal experimentation, Heart transplantation, Baboons

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New islets from old

Article Abstract:

Transplanting Island of Langerhans pancreatic cells could cure diabetes. Stem cell technology could solve the problem of obtaining sufficient numbers of purified cells from a single cadaver pancreas.

Diabetes, Diabetes mellitus, Islands of Langerhans, Islets of Langerhans

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