Incidence and Clinical Course of Thrombotic Thrombocytopenic Purpura Due to Ticlopidine Following Coronary Stenting

Article Abstract:

The anticoagulant drug ticlopidine can cause thrombotic thrombocytopenic purpura (TTP), which can be fatal if not treated. Ticlopidine is often given to patients who are receiving a stent, which is a small cylindrical device inserted into blocked arteries to keep them open. During a one-year period, 19 patients who received ticlopidine developed TTP, which is characterized by anemia, low blood platelet counts and bleeding into the skin. This is an incidence of 1 case of TTP for every 4,814 patients treated, or 0.02%. This is much higher than the 0.0004% incidence of TTP in the general population. Four patients died but none of the 13 who received plasmapheresis died.

Causes of, Complications and side effects, Thrombocytopenic purpura, Ticlopidine

---

Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: A randomized trial

Article Abstract:

A study is conducted to determine the effect of an inhibitor of 5-lipoxygenase-activating protein (FLAP) on levels of biomarkers associated with myocardial infarction (MI) risk. It is concluded that in patients with specific at-risk variants of 2 genes in the leukotriene pathway, DG-031 led to significant and dose-dependent suppression of biomarkers that are associated with increased risk of MI events.

Risk factors, Heart attack, Leukotrienes, Biological markers

---

The Genomics gold rush

Article Abstract:

Human genetic studies have assumed a totally new look with high-throughput genotyping and such genome-wide association studies are very helpful in the detection of most ailments.

Usage, Human genetics, Genetic markers, Medical genetics

Similar abstracts:

• Abstracts: Thrombotic thrombocytopenic purpura. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP
• Abstracts: The clinical efficacy of oral tocolytic therapy. Prior cone biopsy: Prediction of preterm birth by cervical ultrasound
• Abstracts: Build upon strengths and leadership practices using EBP. Developing an integrated falls prevention strategy
• Abstracts: NICE launches new guidelines on managing stress urinary incontinence. Urinary incontinence in women
• Abstracts: New NICE guidance on the secondary prevention of MI. Guidance on treating urinary tract infection in children

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.