Increased serum concentrations of soluble HLA-class I antigens in hepatitis C virus related mixed cryoglobulinaemia

Article Abstract:

Many patients with hepatitis C have increased blood levels of HLA class I heavy chains and beta(sub)2 mu free class I heavy chains. Hepatitis C mostly affects the liver, but it also produces immune and autoimmune disorders.

HLA histocompatibility antigens, HLA antigens

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Mixed cryoglobulinaemia after hepatitis C virus: more and less ambiguity

Article Abstract:

The presence of cryoglobulins in the blood associated with hepatitis C infection needs to be more precisely classified. Cryoglobulins are large immune complexes that precipitate from blood samples at low temperatures and may be present in a number of autoimmune, infectious, and cancerous diseases. The detection of these immune complexes in the presence of disease does not necessarily identify a causal relationship. Depending on which disease symptoms are most prominent, patients may be seen by rheumatologists, gastroenterologists, or other specialists. Neither physician sees the full spectrum of patients with cryoglobulinemia.

United States

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Cryoglobulinaemia and rheumatic manifestations in patients with hepatitis C virus infection

Article Abstract:

Cryoglobulinemia may associated with the immunological changes that accompany hepatitis C infection. Cryoglobulins are immune complexes which precipitate from the blood at low temperatures, and can be present in rheumatoid arthritis and other similar conditions. Researchers in Korea examined 49 patients with hepatitis C and found that 59% had cryoglobulins in their blood. Fourteen percent of patients with cryoglobulinemia also had detectable rheumatoid factor, and 35% of all patients reported joint pain or inflammation. Hepatitis C virus may be associated with some cases of rheumatoid disease of undetermined cause.

South Korea, Rheumatic diseases

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