Enoxaparin treatment in women with mechanical heart valves during pregnancy

Article Abstract:

The anticoagulant drug enoxaparin appears to be safe when given to pregnant women with an artificial heart valve but it may not prevent many blood clots. In a study of 11 women, none had any excessive bleeding or hemorrhage while taking the drug.

Care and treatment, Evaluation, Prevention, Pregnant women, Thromboembolism, Complications, Enoxaparin, Heart valve prosthesis, Artificial heart valves

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Inherited thrombophilias are not increased in "idiopathic" small-for-gestational-age pregnancies

Article Abstract:

Pregnant women who have a tendency to form abnormal blood clots do not have a greater than normal risk for having a small-for-gestational-age baby, according to a study of 290 pregnant women a normal-size baby and 145 pregnant women with a small-for-gestational-age baby. Other studies have shown an increased risk of preeclampsia, placental disorders, and stillbirth in women with this tendency.

Health aspects, Risk factors, Birth weight, Low, Low birth weight, Hypercoagulation

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Necrotizing fasciitis in the puerperium

Article Abstract:

Nonsteroidal antiinflammatory drugs may contribute to necrotizing fasciitis. Necrotizing fasciitis is a sudden and severe group A streptococcal infection that spreads to deep fibrous tissue. A 36-year-old mother began taking a nonsteroidal antiinflammatory drug two days after delivery for symphysis pubis pain. On day four, the patient developed severe shoulder pain and was given narcotic analgesia in addition to the nonsteroidal antiinflammatory drug. Severe sepsis and abdominal distention developed. A laparotomy was performed showing an enlarged uterus and septic thrombosis. A hysterectomy was performed but the necrotizing fasciitis kept spreading. She died on day six. The mother most likely had bacteremia on day two, but sepsis was not suspected because of lack of fever. The nonsteroidal antiinflammatory drug may have delayed the detection of sepsis or predisposed the mother to developing necrotizing fasciitis. Nonsteroidal antiinflammatory drugs may be unsafe for women with sepsis during the period after labor.

Streptococcal infections, Causes of, Complications and side effects, Nonsteroidal anti-inflammatory drugs, Nonsteroidal anti-inflammatory agents, Necrotizing fasciitis

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