Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor way

Article Abstract:

The effects of inhibitors of histone deacetylases (HDACls) on leukemias expressing in PML-RAR or AML1-ETO oncoproteins were investigated. The results show that sensitivity to HDACls in leukemias is a property of the fully transformed phenotype and depends on activation of a specific death pathway.

Leukemia, Oncogenes, Apoptosis

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Autoimmunity and tumor immunity induced by immune responses to mutations in self

Article Abstract:

Black mice were immunized by using combinatorial DNA libraries encoding large numbers of random mutations in two syngeneic tyrosinase-related proteins. Autoimmune hypopigmentation and tumor immunity were induced through cross-recognition of nonmutated gene products by the libraries of mutated DNA.

Genetic aspects, Autoimmunity, Immune response

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B-cell lymphoma: Suppressing a tumor suppressor

Article Abstract:

Diffused large B-cell lymphoma (DLBCL) is an aggressive cancer that accounts for about 40% of non-Hodgkin lymphomas. Phan and Dalla-Favera provided an insight about the operation of BCL-6, showing that BCL-6 can directly repress the transcription of the p53 tumor suppressor gene.

Health aspects, Causes of, Genetic transcription, Transcription (Genetics), Non-Hodgkin's lymphomas, Lymphocytic leukemia

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