Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors

Article Abstract:

CD8+ T cells can mediate eradication of established tumors, and strategies to amplify tumor-reactive T-cell numbers by immunization or ex vivo expansion followed by adoptive transfer are being explored in individuals with cancer. Generating effective CD8+ T cell-mediated responses to tumors is often impeded by T-cell tolerance to relevant tumor antigens, as most of these antigens are also expressed in normal tissues.

CD8 lymphocytes, Interleukin-15

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A fork in the pathway to inflammation and arthritis

Article Abstract:

Neutrophils persist in the joints of individuals with inflammatory arthritis, where they contribute to disease like Rheumatoid arthritis. The molecular basis of this persistence is shown to hinge on the forkhead transcription factor Foxo3a, which ensures neutrophil survival during inflammation by suppressing the induction of Fas ligand, a molecule that promotes programmed cell death.

Risk factors, Neutrophils

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4-1BB-mediated immunotherapy of rheumatoid arthritis

Article Abstract:

Collagen type II-induced arthritis is a CD4+T-cell-dependent chronic inflammation in susceptible DBA/1 mice and represents an animal model of human rheumatoid arthritis. It was found that development of this condition, and even established disease, are inhibited by an agonistic anti-4-1BB monoclonal antibody.

Rheumatoid arthritis

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