Interpreting cost analyses of clinical interventions

Article Abstract:

Reports of clinical trials in medical journals often contain comments about the costs of a medical intervention without providing cost data. Researchers reviewed 181 articles that included statements of cost and found that 53.6% contained actual data. Articles with cost data most often cited operating expenses, such as supplies and personnel, and rarely considered overhead or start-up costs in estimating the cost-effectiveness of a medical treatment or procedure. A standardized protocol for reporting the cost of clinical interventions would help physicians better perform cost-benefit analyses.

Evaluation, Reports, Medical care, Cost of, Health care costs, Cost benefit analysis

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Financial Interest and Its Disclosure in Scientific Publications

Article Abstract:

Biomedical journals can best serve the scientific community and the public by requiring all authors to disclose any financial conflict of interest. The most important conflict of interest is any financial relationship with industry such as employment, consultancies, stock ownership, honoraria, or expert testimony. Some editors believe in prohibiting conflicts of interest whereas others merely require the author to disclose such interests. Journals differ substantially in their requirements to disclose financial interests to editors.

Ethical aspects, Medical publishing, Conflict of interests (Agency), Conflicts of interest

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Scientific and Ethical Issues in Equivalence Trials

Article Abstract:

The difficulties in conducting equivalence trials are discussed. Most clinical trials assume that both treatments are equivalent and then try to determine if one is actually better than the other. An equivalence trial assumes one treatment is better than another and then tries to determine if they are actually equivalent.

Editorial, Drugs

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