Intestinal lymphocyte subsets and turnover are affected by chronic alcohol consumption: Implications for SIV/HIV infection

Article Abstract:

A study testing the hypothesis that exposure to alcohol directly affects the host susceptibility to HIV by influencing the immunologic/physiologic state of host tissues, particularly in the intestinal tract is illustrated. The mucosal immune system is the main target for both HIV and SIV infection as these viruses selectively target and destroys specific subsets of CD4(super +) T-cells that are abundant in mucosal tissues but rare in peripheral lymphoid tissues.

United States, Science & research, Health aspects, Research, Drinking of alcoholic beverages, Drinking (Alcoholic beverages), Lymphocytes

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Participant retention in clinical trials of candidate HIV vaccines

Article Abstract:

The predictors of loss to follow-up (LTFU) in trials of candidate HIV preventive vaccines are determined from the data obtained from trials conducted by the AIDS Vaccine Evaluation Group (AVEG) and HIV Network for Prevention Trials (HIVNET). Younger age and increasing trial duration predicted LTFU.

Product information, Testing, Clinical trials, Drug therapy, AIDS vaccines, Regression analysis

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