Is insulin lispro associated with the development or progression of diabetic retinopathy during pregnancy?

Article Abstract:

The use of insulin lispro by 12 pregnant women with diabetes did not cause the formation or progression of diabetic retinopathy. In fact, 14% of 42 pregnant women who used regular insulin either developed retinopathy or experienced a progression of the disease.

Diseases, Pregnant women, Diabetic retinopathy, Insulin

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High infectious morbidity in pregnant women with insulin-dependent diabetes: an understated complication

Article Abstract:

Diabetics tend to develop infection easily, and this is related to alterations in immune cell activity, especially in subjects with poorly controlled elevated glucose levels. Pregnancy is also associated with increased risk for infection, as immune system function is altered during that time. Thus, pregnant diabetic women are highly likely to develop infections. The risk of infection associated with diabetes was evaluated in 65 diabetic and 65 nondiabetic pregnant women, and the association of infection rate with poor glycemic control in diabetic patients was studied. Eighty-five percent of diabetic women developed infections during pregnancy, compared with an infection rate of only 26 percent in nondiabetic women. Postpartum rates of infection were also higher in diabetic women. Infection rates at all sites were elevated. No particular bacterial species was implicated, but diabetic women did tend to have more infections caused by a common fungus (or yeast), Candida. The results suggested that glycemic control may have been poorer preceding the development of infections in diabetic women. Further research is needed to determine if improved metabolic control will result in a lower risk of infection in diabetic pregnant women. (Consumer Summary produced by Reliance Medical Information, Inc.)

Infection

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Pre-conception management of insulin-dependent diabetes: improvement of pregnancy outcome

Article Abstract:

Proper control of blood glucose (sugar) levels is critical for patients with diabetes. These patients are treated with insulin, a hormone that regulates the amount of glucose in the blood and prevents glucose levels from becoming too high. Several studies have reported that pregnant women with diabetes who do not properly control their blood glucose levels have a greater chance of having a spontaneous abortion (miscarriage) or having an infant with birth defects. In most cases, the woman is not aware that she is pregnant until two or more weeks after conception. For the diabetic, this means that strict control of blood glucose levels is not started until after the critical period of fetal development has begun. Therefore, a study was performed to determine if strict control of blood glucose levels prior to conception reduces the incidence of spontaneous abortion and birth defects in women with diabetes. A clinic was established to help the patients maintain strict control over their blood glucose levels. The study included 28 diabetic women who attended the clinic prior to conception, and 71 who were enrolled in the clinic after conception. The incidence of spontaneous abortion was much lower for the women who attended the clinic prior to conception (7 percent) than for those who enrolled after conception (24 percent). Only one infant was born with a serious birth defect, and it was born to a mother who enrolled in the clinic after conception. It is concluded that for diabetic women, attending a clinic to help maintain strict control of blood glucose levels prior to conception can reduce the incidence of spontaneous abortion. (Consumer Summary produced by Reliance Medical Information, Inc.)

Care and treatment, Information services, Type 1 diabetes, Prenatal care, Pregnancy, Complications of, Pregnancy complications

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