Lack of association between increased antibody levels to mycobacterial hsp65 with rheumatoid arthritis: results from a study of disease discordant twin pairs

Article Abstract:

Increased levels of antibodies against mycobacterial heat shock protein 65 (hsp 65) may not play a role in the development of rheumatoid arthritis (RA). Mycobacterial hsps are produced after infection by Mycobacterium, the bacterium that causes tuberculosis. A study measured blood levels of immunoglobulin G (IgG) against Mycobacterium bovis hsp65 in 152 pairs of twins in which one twin had RA and the other did not. Sixty-two healthy individuals also underwent measurement of their blood levels of IgG against mycobacterial hsp65. Blood levels of IgG in the RA patients were similar to those of their twin and of the healthy individuals. Sixty-four pairs of twins were identical, and 88 were fraternal. An association was found between lower levels of IgG against mycobacterial hsp 65 and the development of RA in the identical twins.

Rheumatoid arthritis, Heat shock proteins

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PPD and hsp65 induced monoarthritis initiates spontaneous recurrent flares in Lewis rats

Article Abstract:

A syndrome similar to rheumatoid arthritis (RA), which is an autoimmune disease, can be induced in rats by sensitizing them to heat shock protein, a type of protein found in the cell walls of certain bacteria. Two different breeds of rats were sensitized by injection with either heat shock protein or purified protein derivative from Mycobacterium tuberculosis. Purified protein derivative was injected into the rats' knee joints seven days later. One breed developed a transient arthritis. The other breed developed a chronic arthritis with intermittent flare-ups, similar to RA. This breed, as do some humans, has a genetic predisposition to develop RA as well as an inborn immune system disorder.

Research, Arthritis, Animal models in research, Animal research models, Synovitis

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Fc-gamma-RIIa polymorphism in systemic lupus erythematosus

Article Abstract:

There may be no association between a white blood cell immune receptor gene and systemic lupus erythematosus (SLE). SLE is a chronic, autoimmune inflammatory disorder of connective tissues and organs. Researchers analyzed the genes of 123 patients with SLE and 118 healthy volunteers in Greece and the UK. No relationship between variants of the Fc-gamma-RIIa gene and symptoms of SLE was detected in this population.

Health aspects, Genetic aspects, Autoimmune diseases, Systemic lupus erythematosus, Genetic polymorphisms

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