Lack of decay of HIV-1 in gut-associated lymphoid tissue reservoirs in maximally suppressed individuals

Article Abstract:

A study was undertaken to determine whether detectable levels of HIV-1 DNA or RNA remain in the gastrointestinal (GI) mucosal of HIV-1-infected, well suppressed subjects on highly active antiretroviral therapy (HAART) and also whether it was possible to identify the decay in those levels. It was observed that HIV-1 RNA was detected in mucosal biopsy specimens from only 20% of the subjects, mucosal HIV-1 DNA was detected in 80% of the subjects, while there was no evidence for decay of the HIV-1 DNA in either gut-associated lymphoid tissue (GALT) or peripheral blood mononuclear cells (PBMCs).

Health aspects, Risk factors, HIV infection, HIV infections, Genetic aspects, Lymphoid tissue, Highly active antiretroviral therapy, Clinical report, MALT lymphoma

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Increased HIV-1 mucosal replication is associated with generalized mucosal cytokine activation

Article Abstract:

An attempt is made to characterize intestinal mucosal cytokine profiles in subjects with HIV-1 infection and their relation to muc os al viral load (MVL). Also, longitudinal data from two patients is included in whom it is possible to measure sequential tissue viral load and cytokine profiles after the initiation and withdrawal of antiretroviral therapy (ART).

AIDS (Disease), AIDS research, Viral load

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A transcription inhibitor, Actinomycin D, enhances HIV-1 replication through an interleukin-6-dependent pathway

Article Abstract:

Identification of the factors produced by MT-2 cells that were responsible for increase in HIV replication induced by ActD is discussed. Results show that ActD induces replication of HIV-1 through modulation of cytokine production.

Genetic transcription, Transcription (Genetics), Dactinomycin

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