Liver disease in patients with hereditary hemorrhagic telangiectasia

Article Abstract:

Cases of liver involvement in patients with hereditary Rendu-Osler-Weber disease indicate hepatic abnormalities. In a study of 19 patients with this autosomal disorder, clinical manifestations show a variety of conditions that include heart-failure, bile duct disease, and liver hypertension.

Statistical Data Included, Risk factors, Physiological aspects, Liver diseases

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Infliximab maintenance therapy for fistulizing Crohn's disease

Article Abstract:

A study on 306 adult patients with fistulizing Crohn's disease to observe their response to induction therapy with infliximab is presented. The likelihood of a sustained response is increased if the infliximab treatment is done every eight weeks over a 54-week period.

Dosage and administration, Crohn's disease, Infliximab

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Hereditary hemorrhagic telangiectasia

Article Abstract:

Hereditary hemorrhagic telangiectasia may occur in many locations throughout the body and may respond favorably to various treatments. Telangiectasia is an abnormal permanent dilation of normal blood vessels in the skin or other mucous membranes resulting in the mixing of arterial and venous blood in the affected area and creating small red lesions. Hereditary hemorrhagic telangiectasia occurs in the stomach, intestinal tracts, brain, lung, skin, and nose. Treatments currently used for this disorder include laser therapy, transcatheter embolotherapy, vascular surgery, and estrogen therapy. Periodic evaluation for telangiectasia in the lung and brain may be advisable for otherwise affected patients. More precise identification of the genetic links to hereditary hemorrhagic telangiectasia may hold promise for future gene replacement therapy.

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