Long-term postmenopausal hormone use, obesity, and fat distribution in older women

Article Abstract:

Hormone therapy in postmenopausal women does not appear to be associated with weight gain or obesity, though women who use such therapy tend to be less obese initially. Researchers interviewed and analyzed height, weight, fat distribution, and body composition in 671 postmenopausal women. The women were evaluated at an initial visit and a follow-up visit 15 years later. Of the women, 194 never used hormone therapy, 331 used it intermittently, and 146 used it continuously between visits. The most common hormone taken was estrogen, though progestin was also taken. At the initial visit, women who continuously received hormones were significantly less obese, after adjustment for age. At follow-up, there were no significant differences between the groups in obesity, fat distribution, or body composition after adjustment for age and initial obesity. Differences were also insignificant with adjustment for tobacco and alcohol consumption, exercise, health behavior, and characteristics of menopause.

Risk factors, Obesity, Aged women, Elderly women

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Of designer drugs, magic bullets, and gold standards

Article Abstract:

It may be premature to prescribe the drug raloxifene for postmenopausal women. This drug is similar to estrogen but does not adversely affect the breast or endometrium. A 1998 study found that raloxifene reduced LDL, or 'bad' cholesterol as much as hormone therapy with estrogen and progestin but did not raise HDL, or 'good' cholesterol as much. It has not been convincingly shown that estrogen replacement therapy reduces mortality rates from heart disease and there is even less data on raloxifene and a similar drug, tamoxifen.

Editorial, Coronary heart disease, Estrogen, Estrogen antagonists

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Hormone Replacement Therapy and Cognition: Systematic Review and Meta-analysis

Article Abstract:

Hormone replacement therapy may reduce the risk of dementia, according to researchers who analyzed 29 studies on the subject. However, many of the studies were not well-designed so further research may be needed on this topic.

Dementia

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