Loss of function of a lupus-associated Fc(gamma)RIIb polymorphism through exclusion from lipid rafts

Article Abstract:

A demonstration that systemic lupus erythematosus (SLE)-associated polymorphism of Fc(gamma)RIIb encoding a single transmembrane amino acid substitution, is functionally impaired is presented. Fc(gamma)RIIbT232 is unable to inhibit activatory receptors because it is excluded from sphingolipid rafts, resulting in the unopposed proinflammatory signaling thought to promote SLE.

Physiological aspects, Lupus erythematosus, Morphological variation

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Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function

Article Abstract:

The levodopa-induced dyskinesia (LID) was associated with the overexpression of D3 receptor. The D3 receptor that participated in both dyskinesia and the therapeutic action of levodopa, and that partial agonists may normalize D3 receptor function and correct side effects of levodopa therapy in patients with PD was indicated with the help of results.

Cell receptors, Movement disorders, Dopa, L-dopa

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