Measured Versus Self-Reported Compliance With Doxycycline Therapy for Chlamydia-Associated Syndromes

Article Abstract:

Many patients may overestimate their compliance with medication. In a study of 221 people treated with doxycycline for a sexually transmitted disease called chlamydia, all were given the medication in a bottle with a Medication Event Monitoring System (MEMS) cap. These caps record each time the bottle is opened. Although 90% reported taking their medication as directed, only 33 patients actually did so according to data obtained from the MEMS cap. Even with this low level of compliance, however, only 6% of follow-up urine cultures were positive for chlamydia.

Measurement

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Treating chlamydial infection: compliance versus cost

Article Abstract:

Research and experience suggest that, even though more costly, supervised single-dose azithromycin treatment should be the routine treatment for patients with chlamydia infections. Multiple-dose doxycycline treatment taken at home can be reserved for patients trusted to complete the medication cycle. Study results have been mixed on the effectiveness of each treatment strategy, possibly explained by study design flaws. Short-term medication costs may, however, far outweigh the long-term health care costs of incompletely treated chlamydia infections.

Editorial, Azithromycin

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Compliance with doxycycline therapy in sexually transmitted diseases clinics

Article Abstract:

Many patients given doxycycline therapy for chlamydia may not take their medication as specified. Specialized caps were used on bottles of doxycycline tablets to monitor how frequently 179 patients took their medication. Only 25% of the patients took their medication exactly as specified with 51% taking it fairly regularly. Twenty-four percent of the patients either delayed treatment for at least two days after being given the medication or regularly skipped medication for entire days.

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