Measured menstrual blood loss in women with a bleeding disorder or using oral anticoagulant therapy

Article Abstract:

Menorrhagia is defined as a blood loss of more than 80 milliliters during a single menstrual cycle following ovulation. Some investigators consider a blood loss of 60 milliliters the upper limit, since this is the level at which many women experience anemia, a reduction in total red blood cells. Menorrhagia is experienced by women with bleeding disorders and women receiving anticoagulation therapy for another medical condition. The extent of blood loss experienced by 11 women on anticoagulation therapy and six women with a bleeding disorder is reported. The average blood loss in the women with a bleeding disorder was 219 milliliters, with a range from 60 to 568 milliliters. Five women with a bleeding disorder were diagnosed with menorrhagia. The average blood loss in the women receiving anticoagulation therapy was 98 milliliters, with a range from 9 to 239 milliliters. Five of the women on anticoagulation therapy had menorrhagia and two had blood losses that were at the high end of normal. The anticoagulant status did not relate to the amount of blood loss. Since women with bleeding disorders are not candidates for the conventional treatment offered to women with menorrhagia, it is suggested instead that levels of hemoglobin (the oxygen-carrying pigment of red blood cells) or ferritin (an iron-containing substance in the body) be controlled. (Consumer Summary produced by Reliance Medical Information, Inc.)

Causes of, Complications and side effects, Physiological aspects, Blood clotting disorders, Blood coagulation disorders, Anticoagulants (Medicine), Anticoagulants

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The effect of low-dose 3-keto-desogestrel added to a copper-releasing intrauterine contraceptive device on menstrual blood loss: a double-blind, dose-finding, placebo-controlled study

Article Abstract:

The Multiload Cu250 intrauterine device that releases 1.5 micrograms of 3-keto-desogestrel daily appears to be effective in treating women with excessive uterine bleeding, according to a study of 203 women. Higher doses of 3-keto-desogestrel were no more effective than the low dose.

Evaluation, Intrauterine contraceptives, Progestational hormones, Intrauterine devices

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In vitro studies of cryoablation of the endometrium

Article Abstract:

The Endocryo cryoprobe can be used to treat excessive uterine bleeding if the probe is kept in direct contact with the endometrium and the temperature is below 30 degrees C. A cryoprobe removes excessive tissue by freezing it.

Equipment and supplies, Surgery, Endometrium, Ablation (Surgery), Cold, Cryotherapy

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