Memantine in moderate-to-severe Alzheimer's disease

Article Abstract:

The drug memantine may be effective for treating Alzheimer's disease, according to a study of 181 patients. This drug blocks the NMDA receptor, which is believed to cause neurodegenerative disease when it is over-stimulated. The patients who took the drug had higher scores on tests of intellectual ability, function, and behavior than patients who took a placebo, or inactive substance.

Anti-Alzheimer's disease agents, Merz Pharmaceuticals

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Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial

Article Abstract:

The drug memantine may benefit Alzheimer patients who are also taking donepezil, according to a study of 404 patients. Patients who took memantine had higher scores on tests of cognition and ability to perform activities of daily living compared to those who took a placebo, or inactive substance. Memantine is an NMDA receptor antagonist.

Forest Laboratories Inc., FRX

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Donepezil for the treatment of agitation in Alzheimer's disease

Article Abstract:

The effectiveness of donepezil to treat agitation among patients suffering from Alzheimer's disease is studied. The results found that donepezil is not effective in reducing agitation.

Patient outcomes, Donepezil, Clinical report

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