Memory may not need reminding

Article Abstract:

Two populations of CD4+T cells, termed 'effector' and 'central memory' T cells are generated after primary Leishmania major infection. Research on mice shows that populations can mediate protection against subsequent infection, and that persistent infection keeps the effector response robust.

United States, T cells, Leishmaniasis

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A live-cell assay to detect antigen-specific CD4(super+) T cells with diverse cytokine profiles

Article Abstract:

An assay to identify antigen-responsive CD4(super +) T cells that overcomes many of the limitations of existing assays is described. Results reveal that stimulated cells expressing tumor necrosis factor (TNF)-alpha interleukin (IL)-2 or interferon (IFN)-gamma is predominantly CD154(super +).

Tumor necrosis factor, CD4 lymphocytes, Tumour necrosis factor, Cytokine receptors

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