Microarray analysis and tumor classification

Article Abstract:

Deoxyribonucleic acid (DNA) microarray analysis was first described as a means to probe the expression of thousands of genes simultaneously and the technique was soon adopted to search for patterns of expression that could be used to classify types of tumors and predict the outcome and response to chemotherapy. A review of some of the basic issues related to the use of microarray data is presented, including the potential limitations of their use.

HEALTH SERVICES, Medical and Diagnostic Laboratories, Cancer Diagnosis, Cancer, Oncogenes, DNA microarrays, Disease/Disorder overview

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Tumor-induced osteomalacia

Article Abstract:

Tumor-induced osteomalacia (TIO) is illustrated by the clinical presentation of a 55-year-old female patient with progressive fatigue, weakness, and muscle and bone pain with fractures. The distinctive clinical characteristics of this syndrome, the advances in diagnosis of TIO, and new insights into the pathophysiology of this disorder are discussed.

United States, Case studies, Causes of, Osteomalacia

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What is a tumor promoter?

Article Abstract:

Tumor promoters, which are non-DNA reactive carcinogens, are discussed in relation to assessment of drug and chemical safety and risk. Topics include the use of transgenic mouse models and the two-stage assay to identify tumor promoters.

Editorial, Research, Environmental aspects, Genetically modified mice, Cocarcinogens, Carcinogens

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