Molecular Diagnosis of Hereditary Nonpolyposis Colorectal Cancer

Article Abstract:

Genetic testing of the general population for mismatch repair (MR) genes associated with colorectal cancer is not yet appropriate, but members of high-risk families may benefit from screening and enhanced disease surveillance. A particular mutation in one of the MR genes may cause up to 80% of affected people to develop colorectal cancer. Hereditary nonpolyposis colorectal cancer is caused by these mutations, which substantially increase the risk of cancer of the colon, rectum, endometrium, and kidneys. High-risk patients with the suspect genes may benefit from regular and frequent colonoscopy, and knowing their higher risk of cancer, patients may be more likely to comply with aggressive preventive care.

Editorial, Statistical Data Included, Evaluation, Colorectal cancer, Genetic aspects, Genetic screening, Genetic testing

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False-Positive Laboratory Tests for Cryptosporidium Involving an Enzyme-Linked Immunosorbent Assay-United States, November 1997-March 1998

Article Abstract:

County and state health departments that notice a sudden increase in the rate of Cryptosporidium infection should investigate the possibility of false-positive test results. This means that the test is erroneously positive although the person is not infected. Between Nov, 1997, and March, 1998, five states reported an increase in the number of people testing positive for Cryptosporidium. However, additional testing of stool samples came up negative. The manufacturer of the tests admitted that some of the tests could produce a false-positive result and recommended discontinuing the use of these tests.

Analysis, Diagnosis, Cryptosporidiosis, False positive reactions

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Discrepancy between the tuberculin skin test and the whole-blood interferon gamma assay for the diagnosis of latent tuberculosis infection in an intermediate tuberculosis-burden country

Article Abstract:

The tuberculin skin test (TST) and the whole-blood interferon gamma (IFN-gamma) assay are compared in the diagnosis of latent tuberculosis (TB) infection according to the intensity of exposure. The results reveal that the IFN-gamma assay is a better indicator of the risk of Mycobacterium tuberculosis infection than TST in a BCG-vaccinated population.

Risk factors, Drug therapy, Mycobacterium tuberculosis, Dosage and administration, BCG vaccines, BCG, Tuberculin test

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