Molecular epidemiology of HIV-1 subtypes in southern China

Article Abstract:

The study assessed the driving forces of the HIV-1 epidemic in Guangxi, China by investigating virologic and epidemiologic data from a cohort of longitudinally followed injection drug users (IDUs) in Binyang and Pingxiang, major urban areas along 2 separate drug routes in the province. The epidemic in Pingxiang may have had multiple introductions of the CRF01_AE epidemic into the city and greater spread through sexual transmission.

China, Sexually transmitted diseases, Risk factors, Epidemiology

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Polymorphism of RANTES chemokine gene promoter is not associated with long-term nonprogressive HIV-1 infection of more than 16 years

Article Abstract:

A cross-sectional genetic association case-control study is conducted to examine the association of the polymorphisms of the RANTES chemokine gene promoter with the long-term nonprogressive HIV-1 infection. The analysis suggests that the single nucleotide polymorphisms (Snips) in the RANTES associated with the long-term nonprogressors (LNTPs) cannot exceed more than sixteen years.

HIV infection, HIV infections, Genetic aspects, Single nucleotide polymorphisms

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The effect of RANTES chemokine genetic variants on early HIV-1 plasma RNA among African American injection drug users

Article Abstract:

The early HIV-1 plasma RNA according to known modifying haplotypes in the chemokine coreceptor CCR5 promoter, CCR2, and RANTES genes are analyzed. It is determined whether genetic variants in the CCR5- promoter and in the RANTES gene encoding the CCR5 ligand altered the initial HIV-1 plasma RNA in a cohort of African American seroincident injection drug users (IDUs).

African Americans, Genetic variation

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