Molecular profile of advanced-stage transitional cell carcinoma of the ovary
Article Abstract:
Several measurable cell characteristics do not seem to help predict survival or distinguish patients with transitional cell ovarian cancer from other types of ovarian cancer. Twenty-nine tissue samples from patients with advanced transitional cell ovarian cancer were examined for genetic content, reproduction rate, and the presence of epidermal growth factor receptor, p53, and HER-2/neu. None of these measurements were significantly related to patient survival time. Samples were evenly mixed between those staining positive or negative for cell markers, having two or not two genetic copies, and fast or slow reproducers.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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Polymorphism for mutation of cytosine to thymine at location 677 in the methylenetetrahydrofolate reductase gene is associated with recurrent early fetal loss
Article Abstract:
A gene mutation that leads to abnormal blood clotting appears to be associated with recurrent miscarriages. The mutation in the methylenetetrahydrofolate reductase gene occurred more frequently in a group of women with recurrent miscarriages compared with a group with no history of miscarriage.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
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Polymorphism of TP53 codon 72 and the risk of cervical cancer among Korean women
Article Abstract:
The genetic polymorphism of the p53 gene that codes arginine at position 72 does not appear to increase the risk of cervical cancer, according to a study of 334 Korean women. The p53 gene is a tumor suppresser gene.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
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