Identification of a gene responsible for familial Wolff-Parkinson-White syndrome

Article Abstract:

A gene mutation on chromosome seven appears to be one cause of a heart arrhythmia called Wolff-Parkinson-White syndrome, according to a study of two families with 31 members who have the syndrome. The mutation is located at 7q34-q36 and affects the gamma2 regulatory subunit of AMP-activated protein kinase.

Wolff-Parkinson-White syndrome

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Identification of a genetic locus for familial atrial fibrillation

Article Abstract:

Some cases of atrial fibrillation may be hereditary. Atrial fibrillation is a common arrhythmia that can increase the risk of stroke. Researchers used gene analysis on blood samples from three families with a history of atrial fibrillation. A likely gene was mapped to chromosome 10 in the region 10q22-q24. This is close to the location of the genes for the alpha-adrenergic and beta-adrenergic receptors. These receptors are involved in the maintenance of heart rhythm.

Atrial fibrillation

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Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy

Article Abstract:

Patients who develop cardiac hypertrophy in middle age or old age may have a gene mutation in cardiac myosin-binding protein C. This protein along with others maintains the structure of heart muscle cells. Researchers used DNA analysis to analyze the gene for cardiac myosin-binding protein C in 16 people who had been diagnosed with hypertrophic cardiomyopathy, a condition caused by overgrowth of parts of the heart. Twelve mutations were found that had never before been identified. A total of 212 family members of these patients also had the mutation but only 58% under the age of 50 had hypertrophic cardiomyopathy.

Cardiomyopathy, Hypertrophic, Hypertrophic cardiomyopathy

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