Myelomeningocele: Characterization of a surgically induced sheep model and its central nervous system similarities and differences to the human disease

Article Abstract:

A study determined how closely the surgically induced sheep myelomeningocele (MMC) model resembles the central nervous system derangements seen in human disease, and identified which aspects of MMC are the result of the early neuronal development defect, and which are secondary to the cerebrospinal fluid (CSF) drainage. Although this sheep MMC-like model reproduces the CSF leak, it suggests CSF leak contributes to hindbrain herniation seen in humans.

Science & research, Research

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An animal model for hemolytic disease of the fetus or newborn in New Zealand White and New Zealand Red rabbits: newborn effects

Article Abstract:

Hemolytic disease of the fetus or newborn in humans can be simulated by transfusing female rabbits with incompatible red blood cells, then breeding them to a male with an incompatible blood type. Researchers compared hemoglobin levels and other blood characteristics in fetal and newborn rabbits from these incompatible pregnancies. Newborn hemoglobin levels were significantly lower in rabbits born of incompatible parents.

Models, Physiological aspects, Erythroblastosis fetalis

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Impact of maternal-fetal surgery for myelomeningocele on the progression of ventriculomegaly in utero

Article Abstract:

The impact of intrauterine myelomeningocele (MMC) repair, that is found to decrease hindbrain herniation and the need for postnatal ventriculoperitoneal shunting, on the progression of ventriculomegaly in utero is examined. It is found that intrauterine MMC repair does not impact the progression of ventriculomegaly.

Development and progression, Ventriculostomy

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