Natural History of Progression After PSA Elevation Following Radical Prostatectomy

Article Abstract:

Many men who have their prostate removed to treat prostate surgery may not develop a recurrence even if their prostate-specific antigen level (PSA) begins to rise. In a study of 1,997 men who had a prostatectomy for prostate cancer and were followed for up to 15 years, the survival rate 15 years after surgery was 82%. In 15% of the men, PSA levels began to rise sometime after surgery. About one-third of these men developed metastatic disease an average of eight years after PSA levels began to rise. Several biochemical characteristics predicted which men would develop metastatic disease.

Physiological aspects, Cancer metastasis

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Pretreatment PSA velocity and risk of death from prostate cancer following external beam radiation therapy

Article Abstract:

An attempt is made to assess whether a greater than 2.0-ng/mL increase in prostate-specific antigen (PSA) level during the year prior to diagnosis is significantly associated with prostate cancer-specific mortality following radiation therapy (RT). It is concluded that the increase in PSA level during the year prior to diagnosis is associated with a significantly higher risk of death due to prostate cancer following RT despite having low-risk disease.

Diagnosis

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Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy

Article Abstract:

A study is conducted to define risk factors for prostate cancer death following radical prostatectomy and to develop tables to risk stratify for prostate cancer-specific survival. It is concluded that clinical parameters could help risk stratify patients for prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy.

HEALTH SERVICES, Medical and Diagnostic Laboratories, Cancer Diagnosis, Patient outcomes, Prostatectomy, Cancer

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