Natural history of cervical neoplasia: overview and update

Article Abstract:

The role of human papilloma virus (HPV) in causing cervical cancer should be taken into account when considering diagnostic and treatment strategies. Current diagnostic and treatment strategies are based an the idea that the development of cancer follows a progressive continuum from mildly abnormal cells to invasive cancer. The concept predates knowledge of HPV. In fact, many low-grade abnormalities result from HPV infection with strains of low cancer-causing potential. They will not progress and many will spontaneously regress. Higher-grade abnormalities may represent infection with HPV strains with high cancer-causing potential.

Development and progression, Papillomavirus infections, Cervix dysplasia

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Reliability and clinical application of fetal RhD genotyping with two different fluorescent duplex polymerase chain reaction assays: three years' experience

Article Abstract:

Two tests are very reliable in detecting RhD incompatibilities between pregnant women and their fetus. Most people have the Rh antigen on their blood cells and are considered Rh+. If a woman's fetus has an incompatible Rh type, serious complications can occur. Researchers used two fluorescent duplex polymerase chain reaction assays to analyze the DNA of 213 fetuses. The assays correctly determined which fetuses had Rh incompatibility.

Testing, Prevention, Rh factor, Erythroblastosis fetalis

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Genotyping of 22 human papillomavirus types by DNA chip in Korean women: comparison with cytologic diagnosis

Article Abstract:

Human papillomavirus (HPV) types 16, 18, and 58 are the major papillomavirus types associated with cervical cancer, according to a study of 685 women who had a Pap test. Of these, 271 were diagnosed with cervical cancer. Seventy-nine percent of the women with cervical cancer were infected with HPV types 16, 18, or 58, according to a DNA microarray used to directly measure the virus in Pap smears.

Papillomaviruses, Papillomavirus, Genotype, Genotypes, DNA microarrays

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