Neural tube defects and elevated homocysteine levels in amniotic fluid

Article Abstract:

Certain neural tube birth defects may be caused by abnormal metabolism of homocysteine. Homocysteine is a chemical compound in the human body whose metabolism is influenced by folate and vitamins B6 and B12. Researchers analyzed the amniotic fluid of fetuses in the midtrimester of pregnancy and the mothers' blood for levels of folate, vitamins B6 and B12, and homocysteine. One group of fetuses was known to have neural tube defects, the other group of fetuses was normal but their mothers were old for being pregnant (ages 36-40). The level of homocysteine was much higher in the amniotic fluid of the neural tube defect group, but the homocysteine levels were similar in the mothers' blood of both groups. Neither gestational age nor maternal age influenced homocysteine levels.

Abnormalities, Folic acid, Neural tube, Neural tube defects, Vitamin B12, Homocystinuria

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Base deficit estimation in is influenced by gestational age, choice of fetal fluid compartment, and algorithm for calculation

Article Abstract:

Umbilical cord blood gases at birth are used to quantify the degree of acidosis and to estimate the extent of fetal exposure and response to hypoxia because sustained fetal hypoxia and development of metabolic acidosis can lead to increased risk of manifest motor and cognitive defects. It is found that gestational age, the choice of fetal fluid compartment and the algorithms decisively influence the calculated values of fetal base deficit in umbilical cord.

Risk factors, Gestational age, Fetal anoxia

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Biochemical analyses of mesenchymal fluid in early pregnancy

Article Abstract:

Biochemical analyses reveal that cysts in the developing fetus contain fluid from the fetal circulation whereas hydatidiform moles contain fluid from the mother's blood. This was the conclusion of a study that measured various biochemicals in fluid samples from hydatidiform moles and fetal cysts. Hydatidiform moles are developing fetal membranes that do not contain any fetal embryo.

Molar pregnancy, Hydatidiform mole, Lymphangioma, Fetal, Fetal lymphangioma, Body fluids

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