Neutralizing antibodies in slowly progressing HIV-1 infection

Article Abstract:

HIV-infected people who do not progress quickly to AIDS may be producing natural antibodies against HIV that can neutralize the virus. Researchers took blood samples from 10 HIV-infected people who had CD4+ T cell counts above 450 and 10 HIV-infected people who had CD4+ T cell counts below 200. The former group was considered to have slowly progressing infection (SPI) and the latter to have rapidly progressing infection (RPI). All 20 people had been infected for more than five years. HIV could be isolated from all 10 samples from the RPI group but from only six samples from the SPI group. Blood serum from both groups was incubated with standard viral strains as well as the patient's own viral strain. All of the serum samples neutralized standard viral strains but only serum from the SPI group consistently neutralized their own viral strain.

Antibody-dependent cell cytotoxicity

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Chemokine receptor polymorphism and autologous neutralizing antibody response in long-term HIV-1 infection

Article Abstract:

Neutralizing antibodies in the blood of some HIV patients may contribute to slow progression of the infection. Researchers compared blood levels of the antibodies in 8 patients with slow progression of their HIV infection and 10 patients with rapid progression of their infection. Slow progressors had an average level of neutralizing antibodies of 8.7, compared to an average of 1.6 in rapid progressors. Not all slow progressors, however, had the neutralizing antibodies. The study also revealed an association between chemokine receptor type and the genetic strain of HIV causing infection.

HIV (Viruses), HIV, Genetic aspects, Genetic polymorphisms, HIV antibodies

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No association of HIV-1 envelope (C2-V3-C3) sequence pattern with long-term nonprogression

Article Abstract:

The sequence of the HIV envelope protein C2-V3-C3 does not appear to predict the progression of HIV infection, according to a study of 10 non-progressors and 9 progressors. Non-progressors are people infected with HIV who remain healthy for up to 10 years or more.

Viral envelopes

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