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No effect of copper supplementation on biochemical markers of bone metabolism in healthy young adult females despite apparently improved copper status

Article Abstract:

This article examines the effects of a four-week copper supplementation protocol on copper status and bone metabolism in healthy young women. Findings indicate that copper supplements improved copper status but did not significantly influence biochemical markers associated with bone reabsorption or formation.

Author: Strain, J. J., Cashman, K. D., Baker, A., Ginty, F., Flynn, A., Bonham, M. P., O'Connor, J. M., Bugel, S., Sandstrom, B.
Publisher: Macmillan Publishing Ltd.
Publication Name: European Journal of Clinical Nutrition
Subject: Health
ISSN: 0954-3007
Year: 2001
Denmark, Ireland, Statistical Data Included, Bones, Physiological aspects, Young women, Metabolism, Dietary supplements

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Inter and intra-individual variations in urinary excretion of pyridinium crosslinks of collagen in healthy young adults

Article Abstract:

There is a relatively large day-to-day variation in urinary excretion of pyridinium crosslinks of collagen, according to research undertaken among 17 postgraduate students aged between 22 and 26. This means that it is necessary to use multiple samples to assess an indidivual's crosslink excretion. No significant difference was seen between males and females in mean urinary excretion of pyridinoline or deoxypyridinoline, expressed on a creatinine basis. Factors affecting crosslink excretion include various dietary factors, resistance exercise and, possibly, the stage of the menstrual cycle in females.

Author: Ginty, F., Flynn, A., Cashman, K.
Publisher: Macmillan Publishing Ltd.
Publication Name: European Journal of Clinical Nutrition
Subject: Health
ISSN: 0954-3007
Year: 1998
Collagen, Excretion

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Effect of dietary copper intakes on biochemical markers of bone metabolism in healthy adult males

Article Abstract:

Increased bone resorption may play a role in the demineralization of bone seen in copper (Cu) deficiency, according to research designed to assess the impact of switching from a medium Cu intake to a diet low or high in Cu on biochemical indices of bone turnover. This research indicated a response to dietary Cu restriction of urinary pyridinium crosslink excretion which can be seen as an early indicator of increased bone turnover which, if it continues, would lead to a marked reduction in bone mass over a prolonged period. Serum Cu and Cp concentration, two widely used putative indices of Cu status, are not affected by dietary depletion or repletion of Cu.

Author: Baker, A., Flynn, A., Harvey, L., Fairweather-Tait, S., Cashman, K., Majask-Newman, G.
Publisher: Macmillan Publishing Ltd.
Publication Name: European Journal of Clinical Nutrition
Subject: Health
ISSN: 0954-3007
Year: 1999
Health aspects, Copper

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Subjects list: Copper in the body, Copper (Nutrient), Research
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