Noninvasive diagnosis of deep venous thrombosis

Article Abstract:

Noninvasive diagnostic methods can be used to successfully detect deep vein thrombosis, especially in patients who have symptoms. Deep vein thrombosis occurs when a blood clot forms in the large veins in the legs, blocking the flow of blood. A review of studies of noninvasive diagnosis found that ultrasound scans of the legs and a technique called impedance plethysmography were accurate in detecting symptomatic deep vein thrombosis, especially in the thigh. These techniques were less accurate in detecting thrombosis in the calf. The techniques were also less accurate in asymptomatic patients.

Evaluation, Diagnosis, Impedance plethysmography, Diagnosis, Ultrasonic, Diagnostic ultrasonography

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Factor V Leiden mutation as a risk factor for recurrent pregnancy loss

Article Abstract:

Pregnant women with the factor V Leiden mutation may have a higher risk of miscarriage. Factor V Leiden is a mutation in a gene for coagulation factor V and causes an increased susceptibility to abnormal blood clotting. Researchers performed a genetic analysis on 113 women with a history of miscarriage and 437 women without such a history. Twice as many women with a history of miscarriage had the factor V Leiden mutation, compared to the women without a history of miscarriage. Abnormal blood clotting in the placenta could lead to miscarriage.

Blood clotting disorders, Blood coagulation disorders, Miscarriage

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Relation of factor V Leiden genotype to risk for acute deep venous thrombosis after joint replacement surgery

Article Abstract:

It is probably not necessary to screen patients scheduled for joint replacement surgery for the factor V Leiden mutation. This mutation in one of the blood clotting factors increases the risk of excessive blood clotting. Researchers used an imaging technique that diagnoses blood clots in the leg veins to detect a condition called deep vein thrombosis in 825 patients following joint replacement surgery. The patients were also tested for the factor V Leiden mutation. Patients with the mutation had no increased risk of deep vein thrombosis.

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