Nonsteroidal anti-inflammatory drugs lower A(beta)42 and change presenilin 1 conformation

Article Abstract:

Reports suggest that some commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) shift the cleavage products of amyloid precursor protein (APP) to shorter, less fibrilogenic forms. A demonstration is presented, using a fluorescence resonance energy transfer method, that A(beta)42-lowering NSAIDs specifically affect the proximity between APP and presenilin 1 and alter persenilin 1 conformation both in vitro and in vivo, suggesting a novel allosteric mechanism of action

Science & research, Health aspects, Nonsteroidal anti-inflammatory drugs, Nonsteroidal anti-inflammatory agents

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Inflammation and Alzheimer disease: the good, the bad, and the ugly

Article Abstract:

Research presented concerns the role of inflammation in the pathogenesis of Alzheimer's disease, focusing on studies that suggest a therapeutic potential in select aspects of the inflammatory response. Research on AD using a mouse model demonstrates that amyloid beta-protein plaques are decreased through the overexpression of the cytokine TGF-beta 1 by way of the activation of immune cells called microglia.

Models, Development and progression, Inflammation

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Amyloid beta vaccination: reduced plaques and improved cognition

Article Abstract:

Research presented concerns the treatment of memory loss in Alzheimer disease (AD), focusing on how the amyloid beta-protein may be linked to the development of senile plaques. Research suggests that AD mice immunized with an amyloid beta-peptide fragment have less learning and memory losses, and the potential benefits of this treatment for humans are discussed.

Physiological aspects, Memory

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