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Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm fetuses

Article Abstract:

A study is conducted to determine whether docosahexaenoic acid increased surfactant production, as reflected by increased dipalmitoyl phosphatidylcholine, in mouse fetal lung and amniotic fluid. The oral administration of docosahexaenoic acid to pregnant mice during pregnancy can induce dipalmitoyl phosphatidylcholine production and secretion, which is the major lipid component of surfactant.

Author: Laposata, Michael, Blanco, Paola G., Ollero, Mario, Alvarez, Juan G., Freedman, steven D., Lopez, Mari C., Comen, Elizabeth
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2004
Science & research, Research, Mice, Mice (Rodents), Pregnancy

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Association of cystic fibrosis with abnormalities in fatty acid metabolism

Article Abstract:

A study was conducted to determine whether humans with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have a similar fatty acid defect in tissues expressing CFTR. The result from the study reveals that alterations in fatty acids are present in CFTR-expressing tissue from subjects with cystic fibrosis.

Author: Laposata, Michael, Freedman, Steven D., Shea, Julie C., Weed, Deborah A., O'Sullivan, Brian P., Blanco, Paola G., Ollero, Mario, Belrud, Andres, Alvarez, Juan G., Regan, Meredith M., Hopper, Isabel K.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
Analysis, Complications and side effects, Cystic fibrosis, Fatty acid metabolism

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Case 1-2007: A 40-year-old woman with epistaxis, hematemesis, and altered mental status

Article Abstract:

A case study of a 40-year-old woman with epistaxis, hematemesis, and altered mental status who had heavy menstrual bleeding for 6 months is presented. The patient was discharged home after 15 days treatment of vitamin K and anticoagulation therapy initially with heparin and later with fondaparinux.

Author: Laposata, Michael, Van Cott, Elizabeth M., Lev, Michael H.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
Case studies, Mental illness, Mental disorders, Nosebleed, Hematemesis, Case study

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Subjects list: United States
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