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Organ transplantation-how much of the promise has been realized?

Article Abstract:

Improvements in immunosuppressive drugs and ancillary care have led to outstanding short-term patient and graft survival rates. Developing methods to induce transplant tolerance as a means to improve graft outcomes and eliminate the requirement for immunosuppression, and expanding the pool of organs for transplantation are the major challenges of the field.

Author: Sykes, Megan, Turka, Laurence A., Lechler, Robert I., Thomson, Angus W.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Usage, Immunosuppressive agents

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Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha-1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

Article Abstract:

The initial results of the strategies of immune suppression and induction of tolerance using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach are reported. A life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels is achieved.

Author: Sachs, David H., Sykes, Megan, Shimizu, Akira, Hisashi, Yosuke, Patience, Clive, Awwad, Michel, Cooper, David K. C., Yamada, Kazuhiko, Hawley, Robert J., Schuurman, Henk-Jan, Yazawa, Koji, Iwanaga, Takehiro, Nuhn, Matthew, Fishman, Jay, O'Malley, Patricia, Nobori, Shuji, Vagefi, Parsia A, Greenstein, Julia
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Animal experimentation, Transferases, Baboons, Xenotransplantation

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Allogenic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

Article Abstract:

Researchers were able to transplant bone marrow into mice without the need for myeloablative treatment. This was done by giving the mice a monoclonal antibody against CD154 and cytotoxic T-lymphocyte antigen 4 immunoglobulin.

Author: Wekerle, Thomas, Kurtz, Josef, Ito, Hiroshi, Ronquillo, Joseph V., Dong, Victor, Zhao, Guiling, Shaffer, Juanita, Sayegh, Mohamed H., Sykes, Megan
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Bone marrow, Bone marrow transplantation, Tissue transplantation, Transplantation, Immunological tolerance, Immunologic tolerance

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Subjects list: Research, United States, Transplantation of organs, tissues, etc., Organ transplantation
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