Osteogenesis imperfecta: rehabilitation and prospects for gene therapy

Article Abstract:

Research is ongoing into several promising treatments for osteogenesis imperfecta (OI). OI is a genetic disorder caused by a mutation in type I collagen, which is the primary structural protein in bones and tendons. Children with OI have delayed growth, delayed motor skills and frequent bone fractures. Braces, surgery and physical therapy are used to strengthen muscles. Growth hormone may also be useful in promoting growth. Cell replacement therapy involves replacing defective collagen cells using a bone marrow transplant. Antisense RNA can also block the production of defective collagen.

Care and treatment, Osteogenesis imperfecta, Bone diseases

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Tau and Parkinson disease

Article Abstract:

A mutation in the gene for the tau protein appears to be involved in Parkinson's disease. The tau protein is associated with microtubules, which are involved in cell division. Abnormal forms of the protein cause an accumulation of filaments in the brain.

Health aspects, Editorial, Gene mutations, Gene mutation, Genetic aspects, Parkinson's disease, Parkinson disease

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