Outcome of assisted reproductive technology

Article Abstract:

Injection of a single sperm into an ovum for fertilization in infertile couples may result in undetected sex-chromosome abnormalities in the offspring. Conventional in vitro fertilization procedures carry some additional risk of multiple pregnancies and obstetrical complications, but the rate of malformations is approximately that seen in ordinary pregnancies. More rigorous and complete data collection on children conceived by these methods would help provide the information necessary to counsel parents considering assisted reproductive techniques.

Pregnancy, Multiple, Multiple pregnancy

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A true hermaphrodite chimera resulting from embryo amalgamation after in vitro fertilization

Article Abstract:

Genetic testing of a young boy conceived by in vitro fertilization determined that he was likely the result of the fusion of two embryos in the uterus. The boy was born with normal male genitalia, but an undescended testicle. Surgical exploration to remove the testicle revealed female reproductive organs within a hernia in the groin. Genetic tests revealed XX/XY chimerism, the presence of genetic material of both genders within a single person. Despite this condition, the boy developed as a completely normal male.

Abnormalities, Causes of, Mosaicism, Human embryo

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High prepregnancy body-mass index - a maternal-fetal risk factor

Article Abstract:

Evidence from several studies suggests that fetuses may be harmed by the uterine environment of obese women. Obesity has been linked to maternal medical complications, such as hypertension and diabetes, as well as problems in labor and delivery. Fetuses of obese women may be less likely to be undersized or delivered early, but more likely to be malformed. A new report suggests obese women may have higher rates of late fetal death. Interventions to reduce this potential fetal risk ought to be investigated.

Obesity, Fetal death

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