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PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia

Article Abstract:

Research describes the development of a DNA-based vaccine targeted to an oncoprotein for treating acute leukemia. Results indicate that the vaccine is effective for survival both as a stand-alone or in combination with all-trans retinoic acid. Data reveal the vaccine's protective effect is through its antibody and increased interferon-alpha production.

Author: Degos, Laurent, Chomienne, Christine, West, Robert, Charron, Dominique, Padua, Rose Ann, Larghero, Jerome, Robin, Marie, Pogam, Carol le, Schlageter, Marie-Helene, Muszlak, Sacha, Fric, Jan, Rousselot, Philippe, Phan, Thi Hai, Mudde, Liesbeth, Teisserenc, Helene, Carpentier, Antoine F., Kogan, Scott, Pla, Marika, Bishop, Michael J., Stevenson, Freda
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
United Kingdom, Evaluation, Drug therapy, Immunity, Immunity (Physiology), Interferon alpha, DNA vaccines, Acute leukemia

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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

Article Abstract:

Inhibitors of histone deacetylases (HDACls) induce, in addition to p21, expression of TRAIL by directly activating the TNFSF10 promoter. Thereby, it triggers tumor-selective death signaling in acute myeloid leukemia (AML) cells and the blasts of individuals with AML.

Author: Altucci, Lucia, Gronemeyer, Hinrich, Nebbioso, Angela, Clarke, Nicole, Voltz, Emilie, Germain, Emmanuelle, Ambrosino, Concetta, Bontempo, Paola, Weisz, Alessandro, Alvarez, Rosana, De Lera, Angel R., Schiavone, Ettore M., Ferara, Felicetto, Bresciani, Francesco
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Science & research, Research, Histones, Chromatin, Acute myelocytic leukemia

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Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL

Article Abstract:

Research has been conducted on the therapeutic and preventive activities of retinoids in cancer. Results indicate that these activities are caused by their ability to modulate the growth and survival or opoptosis of the cancer cells.

Author: Altucci, Lucia, Rossin, Aurelie, Raffelsberger, Wolfgang, Reitmair, Armin, Chomienne, Christine, Gronemeyer, Hinrich
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Italy, Statistical Data Included, Analysis, Prevention, Causes of, Medical research, Cell death, Cancer, Cancer prevention, Leukemia, Ligands, Ligands (Chemistry), Tretinoin

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Subjects list: United States, France, Physiological aspects
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