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Phenotypic assays and sequencing are less sensitive than point mutation assays for detection of resistance in mixed HIV-1 genotypic populations

Article Abstract:

The 151 and 215 amplification refractory mutation system (ARMS) is more accurate than other tests in detecting drug resistance in the virus that causes AIDS. ARMS was compared with T7 sequencing, cycle sequencing, the line probe assay (LiPA) HIV-1 RT test, and the recombinant virus assay (RVA).

Author: De Clercq, E., Hermans, P., Harrer, T., Van Laethem, K., Van Vaerenbergh, K., Schmit, J.-C., Sprecher, S., De Vroey, V., Schuurman, R., Witvrouw, M., Van Wijngaerden, E., Stuyver, L., Van Ranst, M., Desmyter, J., Vandamme, A.-M.
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 1999
Drug resistance in microorganisms, Microbial drug resistance, Identification and classification

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The HIV epidemic in the Amazon basin is driven by prototypic and recombinant HIV-1 subtypes B and F

Article Abstract:

Researchers found substantial genetic diversity in HIV isolates from 31 HIV-infected people in Manaus, Brazil. Subtypes B and F were equally distributed among the patients. Manaus is the main city in the Amazonian rain forest.

Author: Vicente, Ana C.P., Otsuki, Koko, Silva, Nelson B., Castilho, Marcia C., Barros, Flavio S., Pieniazek, Danuta, Hu, Dale, Rayfield, Mark A., Bretas, Gustavo, Tanuri, Amilcar
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
South America

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HIV-1 subtype C in commercial sex workers in Addis Ababa, Ethiopia

Article Abstract:

HIV-1 subtype C continues to be the predominant subtype in Ethiopian prostitutes. Of 150 prostitutes tested, 67 were HIV-positive and 66 had subtype C. The remaining prostitute was infected with subtype D.

Author: Hussein, Mintewab, Abebe, Almaz, Pollakis, Georgios, Brouwer, Margreet, Petros, Beyene, Fontanet, Arnaud L., Rinke de Wit, Tobias F.
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
Diseases, Ethiopia, Prostitutes

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Subjects list: HIV (Viruses), HIV, Genetic aspects, HIV infection, HIV infections
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