Programmed cell death (apoptosis) as a possible pathway to metalloproteinase activation and fetal membrane degradation in premature rupture of membranes

Article Abstract:

Premature rupture of membranes may be caused by a form of natural cell death called apoptosis. In a study of 28 pregnant women, those with premature rupture of membranes had increased expression of genes that cause natural cell death in membrane tissue samples.

Physiological aspects, Metalloenzymes

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Support for an infection-induced apoptotic pathway in human fetal membranes

Article Abstract:

Bacterial lipopolysaccharides may trigger apoptosis in fetal membranes, causing premature rupture of the membranes. Apoptosis is the medical term for natural cell death.

Infection, Uterus

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Distinct molecular events suggest different pathways for preterm labor and premature rupture of membranes

Article Abstract:

Researchers have found molecular differences between premature labor and premature rupture of fetal membranes. They studied the production of matrix metalloproteinases, tissue inhibitor of metalloproteinases, pro-apoptotic proteins and anti-apoptotic proteins. Apoptosis is the medical term for natural cell death.

Premature labor, Metalloproteins

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