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Novel strategies for the treatment of sepsis

Article Abstract:

This article examines the recent trends in the care and treatment of sepsis and the focus on clearly understanding the dynamics of pathophysiological responses during sepsis, namely hyperactive or suppressed immune and inflammatory responses. Research indicates that blocking high-mobility group B1 protein, macrophage migration inhibitory factor, the complement split product , C5a, C5aR, and caspases holds promise for sepsis therapy.

Author: Ward, Peter A., Riedemann, Niels C., Guo, Ren-Feng
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Care and treatment, Drug therapy, Immune response, Immunosuppression, Apoptosis, Sepsis

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Protective effects of C5a blockade in sepsis

Article Abstract:

Sepsis was induced in rats, and the protective effects of C5a blockade studied. Sepsis in humans is difficult to treat and the mortality rate is high. Data indicate that sepsis brings on excessive production of D5a, which compromises the bactericidal function of neutrophils. C5a is a low molecular weight anaphylatoxin and potent agonist for neutrophils and endothelial cells. It has vasopermiability and vasodilating functions.

Author: Ward, Peter A., Huber-Lang, Markus, Warner, Roscoe L., Czermak, Boris J., Sarma, Vidya, Pierson, Carl L., Bless, Nicolas M., Schmal, Hagen, Friede, Hans Peter
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Usage, Endothelium, Rats, Physiology

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Protective effects of C5a blockade in sepsis

Article Abstract:

Protective effects of C5a blockade in sepsis have been studied in rats using cecal ligation and puncture (CLP). In rats depleted of C3, a complement factor, CLP brought very short survival times, while most of those C3-intact and preimmune IgG-treated were dead in 7 days. Blood neutrophils from the latter rats had C5a, a powerful complement activation product, on surfaces.

Author: Ward, Peter A., Warner, Roscoe L., Czermak, Boris J., Sarma, Vidya, Pierson, Carl L., Bless, Nicolas M., Schmal, Hagen, Markus, Huber-Lang, Friedl, Hans Peter
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Cell membranes, Immunocytochemistry, Immunoglobulin G, Hydrogen peroxide

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Subjects list: United States, Physiological aspects, Bacterial infections, Statistical Data Included, Research, Germany, Neutrophils
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