Quantifying viable virus-specific T cells without a priori knowledge of fine epitope specificity

Article Abstract:

A simple and versatile method was developed to detect pathogen-specific T cells without a priori knowledge of peptide specificity or major histocompatibility complex (MHC) restriction elements. The T-cell recognition of APCs by protein transfer (TRAP) procedure detects MHC class I-restricted T cells regardless of their ctyokine profiles or peptide-MHC affinities, and provides a versatile tool for monitoring the phenomenon of antigen-presenting cell (APC) membrane acquisition by antigen-specific T cells.

Identification and classification, T cells, Membrane separation

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Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox

Article Abstract:

Three unreported cases of monkeypox in preimmune individuals at 13, 29, and 48 years after small pox vaccination are identified using independent and internally validated diagnostic approaches with greater than or equal to 95% sensitivity and greater than or equal to 90% specificity for detecting clinical monkeypox infection. It is shown that some predictive immunity probably exists in contemporary subjects who have received smallpox vaccination in the distant past.

Diagnosis, Virus diseases

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Duration of antiviral immunity after smallpox vaccination

Article Abstract:

It is considered to remain possible that smallpox could be intentionally released, even though it was eliminated through the efforts of the World Health Organization Global Eradication Program. The magnitude and duration of antiviral immunity induced by one or more smallpox vaccinations are examined.

Powers and duties, Antiviral agents, World Health Organization

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